Germline BRCA, chemotherapy response scores, and survival in the neoadjuvant treatment of ovarian cancer.

ABSTRACT:

Background

To analyze the effects of BRCA1/2 mutations on chemotherapy response scores (CRS) and survival in a cohort of patients with advanced-stage ovarian cancer who were treated with neoadjuvant chemotherapy (NAC) followed by interval debulking surgery (IDS).

Methods

We retrospectively reviewed the medical records of 169 high-grade serous ovarian cancer patients who underwent a germline BRCA1/2 test and received three cycles of NAC at the Yonsei Cancer Center from 2006 to 2018. Chemotherapy response scores were compared in patients with and without BRCA1/2 mutations. The effects of BRCA1/2 mutations and CRS on survival were evaluated.

Results

BRCA1/2 mutations were detected in 47 (28.1%) of the 169 patients. Overall, 16 (34.0%) patients with BRCA1/2 mutations had

SUBMITTER: Lee YJ 

PROVIDER: S-EPMC7057666 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature