Effector T_H17 Cells Give Rise to Long-Lived T_RM Cells that Are Essential for an Immediate Response against Bacterial Infection.

ABSTRACT: Adaptive immunity provides life-long protection by generating central and effector memory T cells and the most recently described tissue resident memory T (T_RM) cells. However, the cellular origin of CD4 T_RM cells and their contribution to host defense remain elusive. Using IL-17A tracking-fate mouse models, we found that a significant fraction of lung CD4 T_RM cells derive from IL-17A-producing effector (T_H17) cells following immunization with heat-killed Klebsiella pneumonia (Kp). These exT_H17 T_RM cells are maintained in the lung by IL-7, produced by lymphatic endothelial cells. During a memory response, neither antibodies, γδ T cells, nor circulatory T cells are sufficient for the rapid host defense required to eliminate K

SUBMITTER: Amezcua Vesely MC 

PROVIDER: S-EPMC7057720 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature