Immune Correlates of Protection Against Human Cytomegalovirus Acquisition, Replication, and Disease.

ABSTRACT: Human cytomegalovirus (HCMV) is the most common infectious cause of infant birth defects and an etiology of significant morbidity and mortality in solid organ and hematopoietic stem cell transplant recipients. There is tremendous interest in developing a vaccine or immunotherapeutic to reduce the burden of HCMV-associated disease, yet after nearly a half-century of research and development in this field we remain without such an intervention. Defining immune correlates of protection is a process that enables targeted vaccine/immunotherapeutic discovery and informed evaluation of clinical performance. Outcomes in the HCMV field have previously been measured against a variety of clinical end points, including virus acquisition, systemic replication, and progression to disease. Herein we revi

SUBMITTER: Nelson CS 

PROVIDER: S-EPMC7057792 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature