Bi-Directional Communication Between Neurons and Astrocytes Modulates Spinal Motor Circuits.

ABSTRACT: Evidence suggests that astrocytes are not merely supportive cells in the nervous system but may actively participate in the control of neural circuits underlying cognition and behavior. In this study, we examined the role of astrocytes within the motor circuitry of the mammalian spinal cord. Pharmacogenetic manipulation of astrocytic activity in isolated spinal cord preparations obtained from neonatal mice revealed astrocyte-derived, adenosinergic modulation of the frequency of rhythmic output generated by the locomotor central pattern generator (CPG) network. Live Ca2+ imaging demonstrated increased activity in astrocytes during locomotor-related output and in response to the direct stimulation of spinal neurons. Finally, astrocytes were found to respond to neuronally-derived glutamate in

SUBMITTER: Broadhead MJ 

PROVIDER: S-EPMC7057799 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature