Circular RNA expression profiling identifies specific circular RNAs in tongue squamous cell carcinoma.

ABSTRACT: Tongue squamous cell carcinoma (TSCC) is the most frequent type of oral cancer associated with high malignancy. Circular RNAs (circRNAs) are a form of non‑coding RNA with stable and conserved expression in mammalian cells. The aim of the present study was to investigate circRNAs expression profiles in TSCC, and examine the roles and potential mechanisms of circRNA‑081069 (circ_081069). A high‑throughput circRNA microarray analysis of tumor samples and adjacent normal tissues from four patients with TSCC was performed. Bioinformatic analysis was conducted to screen the differentially expressed circRNAs. Reverse transcription‑quantitative PCR was performed to confirm the microarray results. A migration assay and proliferation assay were performed to detect the migratory and proliferative abi

SUBMITTER: Wei T 

PROVIDER: S-EPMC7057816 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature