Elastic deformations mediate interaction of the raft boundary with membrane inclusions leading to their effective lateral sorting.

ABSTRACT: Liquid-ordered lipid domains represent a lateral inhomogeneity in cellular membranes. These domains have elastic and physicochemical properties different from those of the surrounding membrane. In particular, their thickness exceeds that of the disordered membrane. Thus, elastic deformations arise at the domain boundary in order to compensate for the thickness mismatch. In equilibrium, the deformations lead to an incomplete register of monolayer ordered domains: the elastic energy is minimal if domains in opposing monolayers lie on the top of each other, and their boundaries are laterally shifted by about 3 nm. This configuration introduces a region, composed of one ordered and one disordered monolayers, with an intermediate bilayer thickness. Besides, a jump in a local monolayer curvature

SUBMITTER: Pinigin KV 

PROVIDER: S-EPMC7058020 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature