Network-based identification of signature genes KLF6 and SPOCK1 associated with oral submucous fibrosis.

ABSTRACT: The molecular mechanism of oral submucous fibrosis (OSF) is yet to be fully elucidated. The identification of reliable signature genes to screen patients with a high risk of OSF and to provide oral cancer surveillance is therefore required. The present study produced a filtering criterion based on network characteristics and principal component analysis, and identified the genes that were involved in OSF prognosis. Two gene expression datasets were analyzed using meta-analysis, the results of which revealed 1,176 biologically significant genes. A co-expression network was subsequently constructed and weighted gene modules were detected. The pathway and functional enrichment analyses of the present study allowed for the identification of modules 1 and 2, and their respective genes, SPARC (o

SUBMITTER: Singh P 

PROVIDER: S-EPMC7058035 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature