Hyperglycaemia does not increase perfusion deficits after focal cerebral ischaemia in male Wistar rats.

ABSTRACT:

Background

Hyperglycaemia is associated with a worse outcome in acute ischaemic stroke patients; yet the pathophysiological mechanisms of hyperglycaemia-induced damage are poorly understood. We hypothesised that hyperglycaemia at the time of stroke onset exacerbates ischaemic brain damage by increasing the severity of the blood flow deficit.

Methods

Adult, male Wistar rats were randomly assigned to receive vehicle or glucose solutions prior to permanent middle cerebral artery occlusion. Cerebral blood flow was assessed semi-quantitatively either 1 h after middle cerebral artery occlusion using ^99mTc-D, L-hexamethylpropyleneamine oxime (^99mTc-HMPAO) autoradiography or, in a separate study, using quantitative pseudo-continuous arterial spin labelling for

SUBMITTER: Thow LA 

PROVIDER: S-EPMC7058243 | biostudies-literature | 2018 Jan-Dec

REPOSITORIES: biostudies-literature