Factors affecting the electrocardiographic QT interval in malaria: A systematic review and meta-analysis of individual patient data.

ABSTRACT:

Background

Electrocardiographic QT interval prolongation is the most widely used risk marker for ventricular arrhythmia potential and thus an important component of drug cardiotoxicity assessments. Several antimalarial medicines are associated with QT interval prolongation. However, interpretation of electrocardiographic changes is confounded by the coincidence of peak antimalarial drug concentrations with recovery from malaria. We therefore reviewed all available data to characterise the effects of malaria disease and demographic factors on the QT interval in order to improve assessment of electrocardiographic changes in the treatment and prevention of malaria.

Methods and findings

We conducted a systematic review and meta-analysis of individual patient data. We searched cl

SUBMITTER: Chan XHS 

PROVIDER: S-EPMC7058280 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature