Nanoparticles for "two color" ¹⁹F magnetic resonance imaging: Towards combined imaging of biodistribution and degradation.

ABSTRACT: The use of polymeric nanoparticles (NPs) as therapeutics has been steadily increasing over past decades. In vivo imaging of NPs is necessary to advance the therapeutic performance. ¹⁹F Magnetic Resonance Imaging (¹⁹F MRI) offers multiple advantages for in vivo imaging. However, design of a probe for both biodistribution and degradation has not been realized yet. We developed polymeric NPs loaded with two fluorocarbons as promising imaging tools to monitor NP biodistribution and degradation by ¹⁹F MRI. These 200 nm NPs consist of poly(lactic-co-glycolic acid) (PLGA) loaded with perfluoro-15-crown-5 ether (PFCE) and PERFECTA. PERFECTA/PFCE-PLGA NPs have a fractal sphere structure, in which both fluorocarbons are distributed in the polymeric matrix of the frac

SUBMITTER: Koshkina O 

PROVIDER: S-EPMC7058420 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature