Neural correlates of clinical improvement in response to N-acetylcysteine in adolescents with non-suicidal self-injury.

ABSTRACT: Non-suicidal self-injury (NSSI) is a serious clinical problem that is common in adolescents. Novel, biologically-informed approaches for treating NSSI in adolescents are needed to prevent negative outcomes such as chronic NSSI and future suicide attempts. N-acetylcysteine (NAC) has been used successfully to address other conditions that involve repetitive maladaptive behaviors and may have utility in addressing NSSI. This study explored neural circuit changes following an open-label, 8-week trial of NAC in female adolescents with NSSI. We measured whole-brain resting-state functional connectivity (RSFC) of the amygdala and the nucleus accumbens before and after treatment using resting-state functional neuroimaging. Usable neuroimaging data from both pre- and post-treatment were available f

SUBMITTER: Cullen KR 

PROVIDER: S-EPMC7058485 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature