Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure: The 3T Trial.

ABSTRACT:

Objectives

This study compared combination diuretic strategies in acute heart failure (AHF) complicated by diuretic resistance (DR).

Background

Combination diuretic regimens to overcome loop DR are commonly used but with limited evidence.

Methods

This study was a randomized, double-blinded trial in 60 patients hospitalized with AHF and intravenous (IV) loop DR. Patients were randomized to oral metolazone, IV chlorothiazide, or tolvaptan therapy. All patients received concomitant high-dose IV infusions of furosemide. The primary outcome was 48-h weight loss.

Results

The cohort exhibited DR prior to enrollment, producing 1,188 ± 476 ml of urine in 12 h during high-dose loop diuretic therapy (IV furosemide: 612 ± 439 mg/day). All 3 interventions significantly impr

SUBMITTER: Cox ZL 

PROVIDER: S-EPMC7058489 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature