Abnormal distraction and load-specific connectivity during working memory in cognitively normal Parkinson's disease.

ABSTRACT: Visuospatial working memory impairments are common in Parkinson's disease (PD), yet the underlying neural mechanisms are poorly understood. The present study investigated abnormalities in context-dependent functional connectivity of working memory hubs in PD. Cognitively normal PD and control participants underwent fMRI while performing a visuospatial working memory task. To identify sources of dysfunction, distraction, and load-modulated connectivity were disentangled for encoding and retrieval phases of the task. Despite normal working memory performance in PD, two features of abnormal connectivity were observed, one due to a loss in normal context-related connectivity and another related to upregulated connectivity of hubs for which the controls did not exhibit context-dependent connect

SUBMITTER: Harrington DL 

PROVIDER: S-EPMC7058508 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature