Rapid tissue processing using a temperature-controlled collection device to preserve tumor biomarkers.

ABSTRACT: Precision tissue diagnostics rely on high quality input specimens so that assay results are not affected by artifact, but advances in collection and processing of tissue specimens have lagged behind innovations in diagnostic assay development. Therefore, we have designed and evaluated a novel surgical tissue collection device that maintains and monitors sample temperature and motion throughout transport so that the major preanalytical variable of tissue temperature can be controlled and measured. This device, in combination with an improved cold-hot tissue fixation protocol affords optimal biomarker preservation in less overall time, thereby simultaneously improving diagnostic quality and turnaround time. We collected 50 primary and metastatic liver tumors using a novel transport device. T

SUBMITTER: Lerch M 

PROVIDER: S-EPMC7058599 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature