Diffuse reflectance spectroscopy to monitor murine colorectal tumor progression and therapeutic response.

ABSTRACT:

Significance

Many studies in colorectal cancer (CRC) use murine ectopic tumor models to determine response to treatment. However, these models do not replicate the tumor microenvironment of CRC. Physiological information of treatment response derived via diffuse reflectance spectroscopy (DRS) from murine primary CRC tumors provide a better understanding for the development of new drugs and dosing strategies in CRC.

Aim

Tumor response to chemotherapy in a primary CRC model was quantified via DRS to extract total hemoglobin content (tHb), oxygen saturation (StO2), oxyhemoglobin, and deoxyhemoglobin in tissue.

Approach

A multimodal DRS and imaging probe (0.78 mm outside diameter) was designed and validated to acquire diffuse spectra longitudinally-via endoscopic guidance

SUBMITTER: Mundo AI 

PROVIDER: S-EPMC7058691 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature