Plasma levels of protein C pathway proteins and brain magnetic resonance imaging volumes in multiple sclerosis.

ABSTRACT:

Background and purpose

The involvement of protein C (PC) pathway components in multiple sclerosis (MS) has scarcely been explored. The aim was to investigate their levels in relation to clinical and neurodegenerative magnetic resonance imaging (MRI) outcomes in patients.

Methods

In all, 138 MS patients and 42 healthy individuals were studied. PC, protein S (PS) and soluble endothelial protein C receptor (sEPCR) were evaluated by multiplex assays and enzyme-linked immunosorbent assay. Regression analyses between 3 T MRI outcomes and PC pathway components were performed. ancova was used to compare MRI volumes based on protein level quartiles. Partial correlation was assessed amongst levels of PC pathway components and hemostasis protein levels, including soluble thrombomodulin

SUBMITTER: Ziliotto N 

PROVIDER: S-EPMC7058813 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature