Simplified drug efficacy screening system for sleep-disorder drugs using non-human primates.

ABSTRACT: The most widely used animal models to develop sleep-disorder drugs are rodents, particularly rats and mice. However, unlike humans, these rodents are nocturnal. Thus, diurnal non-human primates represent a valuable and more translational animal model to study sleep. Although sleep-disorder drugs have been screened in non-human primates, the use of a telemetry system is not a desirable method for a rapid drug efficacy assessment system because of the need for expensive equipment, complicated surgery, and the long time before results can be obtained from analysis by inspection. Locomotor activity has traditionally been used as an indicator of the effects of drugs, genes, and disease models. The Nano-Tag, a new device for analyzing activity after an easy implantation surgery, measures locomot

SUBMITTER: Sakai K 

PROVIDER: S-EPMC7058904 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature