Stretch-Induced Increases in Intracellular Ca Stimulate Thick Ascending Limb O₂^- Production and Are Enhanced in Dahl Salt-Sensitive Rats.

ABSTRACT: Mechanical stretch raises intracellular Ca (Ca_i) in many cell types. Luminal flow-derived stretch stimulates O₂^- production by thick ascending limbs (THALs). Renal O₂^- is greater in Dahl salt-sensitive (SS) than salt-resistant (SR) rats. We hypothesized that mechanical stretch stimulates Ca influx via TRPV4 (transient receptor potential vanilloid type 4) which in turn raises Ca_i in THALs; these increases in Ca_i are necessary for stretch to augment O₂^- production; and stretch-stimulated, and therefore flow-induced, O₂^- production is enhanced in SS compared with SR THALs due to elevated Ca influx and increased Ca_i. Ca_i and O₂^- we

SUBMITTER: Saez F 

PROVIDER: S-EPMC7058965 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature