Epigenetic Modifications in T Cells: The Role of DNA Methylation in Salt-Sensitive Hypertension.

ABSTRACT: The SS (Dahl salt sensitive) rat is an established model of hypertension and renal damage that is accompanied with immune system activation in response to a high-salt diet. Investigations into the effects of sodium-independent and dependent components of the diet were shown to affect the disease phenotype with SS/MCW (JrHsdMcwi) rats maintained on a purified diet (AIN-76A) presenting with a more severe phenotype relative to grain-fed SS/CRL (JrHsdMcwiCrl) rats. Since contributions of the immune system, environment, and diet are documented to alter this phenotype, this present study examined the epigenetic profile of T cells isolated from the periphery and the kidney from these colonies. T cells isolated from kidneys of the 2 colonies revealed that transcriptomic and functional differences

SUBMITTER: Dasinger JH 

PROVIDER: S-EPMC7058976 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature