MicroRNA exporter HuR clears the internalized pathogens by promoting pro-inflammatory response in infected macrophages.

ABSTRACT: HuR is a miRNA derepressor protein that can act as miRNA sponge for specific miRNAs to negate their action on target mRNAs. Here we have identified how HuR, by inducing extracellular vesicles-mediated export of miRNAs, ensures robust derepression of miRNA-repressed cytokines essential for strong pro-inflammatory response in activated mammalian macrophages. Leishmania donovani, the causative agent of visceral leishmaniasis, on the contrary alters immune response of the host macrophage by a variety of complex mechanisms to promote anti-inflammatory response essential for the survival of the parasite. We have found that during Leishmania infection, the pathogen targets HuR to promote onset of anti-inflammatory response in mammalian macrophages. In infected macrophages, Leishmania also upregul

SUBMITTER: Goswami A 

PROVIDER: S-EPMC7059013 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature