Distinct Processing of Aversive Experience in Amygdala Subregions.

ABSTRACT:

Background

The amygdala is an anatomically complex medial temporal brain structure whose subregions are considered to serve distinct functions. However, their precise role in mediating human aversive experience remains ill understood.

Methods

We used functional magnetic resonance imaging in 39 healthy volunteers with varying levels of trait anxiety to assess distinct contributions of the basolateral amygdala (BLA) and centromedial amygdala to anticipation and experience of aversive events. Additionally, we examined the relationship between any identified functional subspecialization and measures of subjective reported aversion and trait anxiety.

Results

Our results show that the centromedial amygdala is responsive to aversive outcomes but insensitive to predictive ave

SUBMITTER: Michely J 

PROVIDER: S-EPMC7059109 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature