Evaluating the Use of Circulating MicroRNA Profiles for Lung Cancer Detection in Symptomatic Patients.

ABSTRACT:

Importance

The overall low survival rate of patients with lung cancer calls for improved detection tools to enable better treatment options and improved patient outcomes. Multivariable molecular signatures, such as blood-borne microRNA (miRNA) signatures, may have high rates of sensitivity and specificity but require additional studies with large cohorts and standardized measurements to confirm the generalizability of miRNA signatures.

Objective

To investigate the use of blood-borne miRNAs as potential circulating markers for detecting lung cancer in an extended cohort of symptomatic patients and control participants.

Design, setting, and participants

This multicenter, cohort study included patients from case-control and cohort studies (TREND and COSYCONET) with 3102

SUBMITTER: Fehlmann T 

PROVIDER: S-EPMC7059111 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature