Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures.

ABSTRACT: When humans age, changes in body composition arise along with lifestyle-associated disorders influencing fitness and physical decline. Here we provide a comprehensive view of dietary intake, physical activity, gut microbiota (GM), and host metabolome in relation to physical fitness of 207 community-dwelling subjects aged +65 years. Stratification on anthropometric/body composition/physical performance measurements (ABPm) variables identified two phenotypes (high/low-fitness) clearly linked to dietary intake, physical activity, GM, and host metabolome patterns. Strikingly, despite a higher energy intake high-fitness subjects were characterized by leaner bodies and lower fasting proinsulin-C-peptide/blood glucose levels in a mechanism likely driven by higher dietary fiber intake, physical ac

SUBMITTER: Castro-Mejia JL 

PROVIDER: S-EPMC7059135 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature