Transcriptome analysis reveals the difference between "healthy" and "common" aging and their connection with age-related diseases.

ABSTRACT: A key goal of aging research was to understand mechanisms underlying healthy aging and develop methods to promote the human healthspan. One approach is to identify gene regulations unique to healthy aging compared with aging in the general population (i.e., "common" aging). Here, we leveraged Genotype-Tissue Expression (GTEx) project data to investigate "healthy" and "common" aging gene expression regulations at a tissue level in humans and their interconnection with diseases. Using GTEx donors' disease annotations, we defined a "healthy" aging cohort for each tissue. We then compared the age-associated genes derived from this cohort with age-associated genes from the "common" aging cohort which included all GTEx donors; we also compared the "healthy" and "common" aging gene expressions wi

SUBMITTER: Zeng L 

PROVIDER: S-EPMC7059150 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature