Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice.

ABSTRACT: Senescent cells accumulate with age in vertebrates and promote aging largely through their senescence-associated secretory phenotype (SASP). Many types of stress induce senescence, including genotoxic stress. ERCC1-XPF is a DNA repair endonuclease required for multiple DNA repair mechanisms that protect the nuclear genome. Humans or mice with reduced expression of this enzyme age rapidly due to increased levels of spontaneous, genotoxic stress. Here, we asked whether this corresponds to an increased level of senescent cells. p16^Ink4a and p21^Cip1 mRNA were increased ~15-fold in peripheral lymphocytes from 4- to 5-month-old Ercc1^-/∆ and 2.5-year-old wild-type (WT) mice, suggesting that these animals exhibit a similar biological age. p16^Ink4a and p2

SUBMITTER: Yousefzadeh MJ 

PROVIDER: S-EPMC7059165 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature