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Comparison of survival outcomes between radio-chemotherapy and radical hysterectomy with postoperative standard therapy in patients with stage IB1 to IIA2 cervical cancer: long-term oncological outcome analysis in 37 Chinese hospitals.


ABSTRACT: BACKGROUND:This study aimed to compare the survival outcomes of radio-chemotherapy (R-CT) and radical hysterectomy with postoperative standard therapy (RH) in stage IB1-IIA2 cervical cancer patients. METHODS:Based on the large amount of diagnostic and treatment cervical cancer data in China, a real-world study and 1:1 case-control matching were used to compare overall survival (OS) and disease-free survival (DFS) in cervical cancer patients. RESULTS:In this real-world study, the 5-year OS and DFS in the R-CT group (n?=?8949) were lower than those in the RH group (n?=?18,152). After applying the inclusion criteria, the OS and DFS in the R-CT group (n?=?582) were lower than those in the RH group (n?=?4308). After 1:1 case-control matching, the 5-year OS and DFS in the R-CT group (n?=?535) were lower than those in the RH group (n?=?535) (OS: 76.1% vs. 84.6%, p?

SUBMITTER: Liu P 

PROVIDER: S-EPMC7059275 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Comparison of survival outcomes between radio-chemotherapy and radical hysterectomy with postoperative standard therapy in patients with stage IB1 to IIA2 cervical cancer: long-term oncological outcome analysis in 37 Chinese hospitals.

Liu Ping P   Lin Lihong L   Kong Yanxiang Y   Huo Zhifeng Z   Zhu Lin L   Bin Xiaonong X   Lang Jinghe J   Chen Chunlin C  

BMC cancer 20200306 1


<h4>Background</h4>This study aimed to compare the survival outcomes of radio-chemotherapy (R-CT) and radical hysterectomy with postoperative standard therapy (RH) in stage IB1-IIA2 cervical cancer patients.<h4>Methods</h4>Based on the large amount of diagnostic and treatment cervical cancer data in China, a real-world study and 1:1 case-control matching were used to compare overall survival (OS) and disease-free survival (DFS) in cervical cancer patients.<h4>Results</h4>In this real-world study  ...[more]

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