Melatonin receptor agonist protects against acute lung injury induced by ventilator through up-regulation of IL-10 production.

ABSTRACT:

Background

It is well known that ventilation with high volume or pressure may damage healthy lungs or worsen injured lungs. Melatonin has been reported to be effective in animal models of acute lung injury. Melatonin exerts its beneficial effects by acting as a direct antioxidant and via melatonin receptor activation. However, it is not clear whether melatonin receptor agonist has a protective effect in ventilator-induced lung injury (VILI). Therefore, in this study, we determined whether ramelteon (a melatonin receptor agonist) can attenuate VILI and explore the possible mechanism for protection.

Methods

VILI was induced by high tidal volume ventilation in a rat model. The rats were randomly allotted into the following groups: control, control+melatonin, control+ramelteon,

SUBMITTER: Wu GC 

PROVIDER: S-EPMC7059294 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature