Validation and modification of staging Systems for Poorly Differentiated Pancreatic Neuroendocrine Carcinoma.

ABSTRACT: BACKGROUND:The American Joint Committee on Cancer (AJCC) and the European Neuroendocrine Tumor Society (ENETS) staging classifications are two broadly used systems for pancreatic neuroendocrine tumors. This study aims to identify the most accurate and useful tumor-node-metastasis (TNM) staging system for poorly differentiated pancreatic neuroendocrine carcinomas (pNECs). METHODS:An analysis was performed to evaluate the application of the ENETS, 7th edition (7th) AJCC and 8th edition (8th) AJCC staging classifications using the Surveillance, Epidemiology, and End Results (SEER) registry (N = 568 patients), and a modified system based on the analysis of the 7th AJCC classification was proposed. RESULTS:In multivariable analyses, only the 7th AJCC staging system allocated patients into four

SUBMITTER: Wang H 

PROVIDER: S-EPMC7059325 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature