Predictable modulation of cancer treatment outcomes by the gut microbiota.

ABSTRACT: The gut microbiota has the potential to influence the efficacy of cancer therapy. Here, we investigated the contribution of the intestinal microbiome on treatment outcomes in a heterogeneous cohort that included multiple cancer types to identify microbes with a global impact on immune response. Human gut metagenomic analysis revealed that responder patients had significantly higher microbial diversity and different microbiota compositions compared to non-responders. A machine-learning model was developed and validated in an independent cohort to predict treatment outcomes based on gut microbiota composition and functional repertoires of responders and non-responders. Specific species, Bacteroides ovatus and Bacteroides xylanisolvens, were positively correlated with treatment outcomes. Oral

SUBMITTER: Heshiki Y 

PROVIDER: S-EPMC7059390 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature