Loss of CELF6 RNA binding protein impairs cocaine conditioned place preference and contextual fear conditioning.

ABSTRACT: In addition to gene expression differences in distinct cell types, there is substantial post-transcriptional regulation driven in part by RNA binding proteins (RBPs). Loss-of-function RBP mutations have been associated with neurodevelopmental disorders, such as Fragile-X syndrome and syndromic autism. Work performed in animal models to elucidate the influence of neurodevelopmental disorder-associated RBPs on distinct behaviors has showed a connection between normal post-transcriptional regulation and conditioned learning. We previously reported cognitive inflexibility in a mouse model null for the RBP CUG-BP, Elav-like factor 6 (CELF6), which we also found to be associated with human autism. Specifically, these mice failed to potentiate exploratory hole-poking behavior in response to famil

SUBMITTER: Maloney SE 

PROVIDER: S-EPMC7059558 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature