Advanced paternal age directly impacts mouse embryonic placental imprinting.

ABSTRACT: The placental epigenome plays a critical role in regulating mammalian growth and development. Alterations to placental methylation, often observed at imprinted genes, can lead to adverse pregnancy complications such as intrauterine growth restriction and preterm birth. Similar associations have been observed in offspring derived from advanced paternal age fathers. As parental age at time of conception continues to rise, the impact of advanced paternal age on these reproductive outcomes is a growing concern, but limited information is available on the molecular mechanisms affected in utero. This longitudinal murine research study thus investigated the impact of paternal aging on genomic imprinting in viable F1 embryonic portions of the placentas derived from the same paternal males when the

SUBMITTER: Denomme MM 

PROVIDER: S-EPMC7059926 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature