Erythropoietin accelerates the revascularization of transplanted pancreatic islets.

ABSTRACT:

Background and purpose

Pancreatic islet transplantation is a promising therapeutic approach for Type 1 diabetes. A major prerequisite for the survival of grafted islets is a rapid revascularization after transplantation. Erythropoietin (EPO), the primary regulator of erythropoiesis, has been shown to promote angiogenesis. Therefore, we investigated in this study whether EPO improves the revascularization of transplanted islets.

Experimental approach

Islets from FVB/N mice were transplanted into dorsal skinfold chambers of recipient animals, which were daily treated with an intraperitoneal injection of EPO (500 IU·kg^-1 ) or vehicle (control) throughout an observation period of 14 days. In a second set of experiments, animals were only pretreated with EPO over a 6-d

SUBMITTER: Menger MM 

PROVIDER: S-EPMC7060362 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature