Screening and identification of MicroRNAs expressed in perirenal adipose tissue during rabbit growth.

ABSTRACT: BACKGROUND:MicroRNAs (miRNAs) regulate adipose tissue development, which are closely related to subcutaneous and intramuscular fat deposition and adipocyte differentiation. As an important economic and agricultural animal, rabbits have low adipose tissue deposition and are an ideal model to study adipose regulation. However, the miRNAs related to fat deposition during the growth and development of rabbits are poorly defined. METHODS:In this study, miRNA-sequencing and bioinformatics analyses were used to profile the miRNAs in rabbit perirenal adipose tissue at 35, 85 and 120 days post-birth. Differentially expressed (DE) miRNAs between different stages were identified by DEseq in R. Target genes of DE miRNAs were predicted by TargetScan and miRanda. To explore the functions of identified m

SUBMITTER: Wang G 

PROVIDER: S-EPMC7060515 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature