How can health economics be used in the design and analysis of adaptive clinical trials? A qualitative analysis.

ABSTRACT:

Introduction

Adaptive designs offer a flexible approach, allowing changes to a trial based on examinations of the data as it progresses. Adaptive clinical trials are becoming a popular choice, as the prudent use of finite research budgets and accurate decision-making are priorities for healthcare providers around the world. The methods of health economics, which aim to maximise the health gained for money spent, could be incorporated into the design and analysis of adaptive clinical trials to make them more efficient. We aimed to understand the perspectives of stakeholders in health technology assessments to inform recommendations for the use of health economics in adaptive clinical trials.

Methods

A qualitative study explored the attitudes of key stakeholders-including rese

SUBMITTER: Flight L 

PROVIDER: S-EPMC7060544 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature