Genetic predisposition to smoking is associated with risk of rheumatoid arthritis: a Mendelian randomization study.

ABSTRACT:

Background

Although observational epidemiological studies have found that smoking is positively associated with risk of rheumatoid arthritis (RA), assessing the causality of this relationship has remained elusive because conventional observational studies are susceptible to bias such as confounding and reverse causation. Here, we applied the Mendelian randomization (MR) approach to examine the potential causal relationship between smoking and risk of RA.

Methods

Summary statistics data for RA were obtained from a meta-analysis of genome-wide association studies (GWAS), including 14,361 RA cases and 43,923 controls of European ancestry. The instrumental variables (IV) and the genetic association estimates for smoking initiation and lifetime smoking were obtained from a GWAS m

SUBMITTER: Qian Y 

PROVIDER: S-EPMC7060545 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature