Identification of the initial molecular changes in response to circulating angiogenic cells-mediated therapy in critical limb ischemia.

ABSTRACT:

Background

Critical limb ischemia (CLI) constitutes the most aggressive form of peripheral arterial occlusive disease, characterized by the blockade of arteries supplying blood to the lower extremities, significantly diminishing oxygen and nutrient supply. CLI patients usually undergo amputation of fingers, feet, or extremities, with a high risk of mortality due to associated comorbidities. Circulating angiogenic cells (CACs), also known as early endothelial progenitor cells, constitute promising candidates for cell therapy in CLI due to their assigned vascular regenerative properties. Preclinical and clinical assays with CACs have shown promising results. A better understanding of how these cells participate in vascular regeneration would significantly help to potentiate their rol

SUBMITTER: Beltran-Camacho L 

PROVIDER: S-EPMC7060566 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature