The effects of testosterone on bone health in males with testosterone deficiency: a systematic review and meta-analysis.

ABSTRACT:

Background

Testosterone deficiency (TD) may induce a series of clinical symptoms. Studies have shown that testosterone supplementation may prevent these unfavourable symptoms and improve patients' quality of life. Given the conflicting findings across studies, this systematic review aims to evaluate the effects and risks associated with testosterone supplementation in middle-aged or aging males with TD.

Methods

Electronic databases (MEDLINE, EMBASE, PubMed, and Cochrane. Library were searched to December 2019. The risk of bias of individual included studies and the quality of the aggregate evidence were assessed using the GRADE approach. Our primary outcome was bone mineral density (BMD). Meta-analyses were performed. This systematic review was reported according to the PRIS

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC7060639 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature