Endothelial-specific YY1 governs sprouting angiogenesis through directly interacting with RBPJ.

ABSTRACT: Angiogenesis, the formation of new blood vessels, is tightly regulated by gene transcriptional programs. Yin Ying 1 (YY1) is a ubiquitously distributed transcription factor with diverse and complex biological functions; however, little is known about the cell-type-specific role of YY1 in vascular development and angiogenesis. Here we report that endothelial cell (EC)-specific YY1 deletion in mice led to embryonic lethality as a result of abnormal angiogenesis and vascular defects. Tamoxifen-inducible EC-specific YY1 knockout (YY1^iΔEC ) mice exhibited a scarcity of retinal sprouting angiogenesis with fewer endothelial tip cells. YY1^iΔEC mice also displayed severe impairment of retinal vessel maturation. In an ex vivo mouse aort

SUBMITTER: Zhang S 

PROVIDER: S-EPMC7060702 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature