The role of critical micellization concentration in efficacy and toxicity of supramolecular polymers.

ABSTRACT: The inception and development of supramolecular chemistry have provided a vast library of supramolecular structures and materials for improved practice of medicine. In the context of therapeutic delivery, while supramolecular nanostructures offer a wide variety of morphologies as drug carriers for optimized targeting and controlled release, concerns are often raised as to how their morphological stability and structural integrity impact their in vivo performance. After intravenous (i.v.) administration, the intrinsic reversible and dynamic feature of supramolecular assemblies may lead them to dissociate upon plasma dilution to a concentration below their critical micellization concentration (CMC). As such, CMC represents an important characteristic for supramolecular biomaterials design, b

SUBMITTER: Su H 

PROVIDER: S-EPMC7060728 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature