Longitudinal flortaucipir ([¹⁸F]AV-1451) PET imaging in primary progressive apraxia of speech.

ABSTRACT: Primary progressive apraxia of speech (PPAOS) is a term used to describe a neurodegenerative condition in which apraxia of speech (AOS; a planning and/or programming deficit) occurs in the absence of aphasia (a language deficit). PPAOS is strongly associated with 4-repeat tau pathology. Elevated flortaucipir ([¹⁸F]AV-1451; FTP) uptake has been observed cross-sectionally in patients with PPAOS and those with aphasia. Here, we evaluated longitudinal changes in previously-identified regions of uptake and their relationship with clinical presentation. Thirteen patients who were diagnosed with PPAOS (5 female) at presentation underwent FTP PET imaging at two visits (mean 1 year interval). Median age was 72, with a median of 4 years disease duration at initial testing. Beta-amyloid st

SUBMITTER: Utianski RL 

PROVIDER: S-EPMC7060829 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature