Albumin promotes proliferation of G1 arrested serum starved hepatocellular carcinoma cells.

ABSTRACT: Albumin is the most abundant plasma protein and functions as a transport molecule that continuously interacts with various cell types. Because of these properties, albumin has been exploited by the pharmaceutical industry to improve drug delivery into target cells. The immediate effects of albumin on cells, however, require further understanding. The cell interacting properties and pharmaceutical applications of albumin incentivises continual research into the immediate effects of albumin on cells. The HepG2/C3A hepatocellular carcinoma cell line is used as a model for studying cancer pathology as well as liver biosynthesis and cellular responses to drugs. Here we investigated the direct effect of purified albumin on HepG2/C3A cell proliferation in the absence of serum, growth factors and

SUBMITTER: Ibrahim B 

PROVIDER: S-EPMC7060934 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature