Effect of biologics in the level of cytokines in the synovial fluid of patients with ankylosing spondylitis.

ABSTRACT:

Background/aims

Biologics are very effective drugs for patients with ankylosing spondylitis (AS). However, there are patients who are not responding to biologics. This study aimed to evaluate the level of tumor necrosis factor α (TNF-α), interleukin (IL)-23, and IL-17 from synovial fluid in patients with AS and rheumatoid arthritis (RA) and differences of the level of those cytokines according to drugs.

Methods

Synovial fluid was obtained from 34 patients (42 samples) with AS and 45 patients (47 samples) with RA with active arthritis of the knee, and the cytokine levels were measured. The differences in the levels between patients treated with and without biologics (biologics and non-biologics groups, respectively) were analyzed in AS and RA. The correlations between cytokin

SUBMITTER: Koo BS 

PROVIDER: S-EPMC7060997 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature