The role of down staging treatment in the management of locally advanced intrahepatic cholangiocarcinoma: Review of literature and pooled analysis.

ABSTRACT:

Backgrounds/aims

Approximately 60-80% of patients with intrahepatic cholangiocarcinoma (iCCA) are not suitable for surgical resection due to advanced disease at presentation. This review assesses the role of surgical resection followed by down staging treatment in the management of patients with locally advanced iCCA.

Methods

A systematic review and pooled analysis were performed of the relevant published studies published between January 2000-December 2018. The primary outcome measure was overall survival. Secondary outcome measures were rates of clinical benefit, margin-negative (R0) resections, overall and surgery-specific complications, and post-operative mortality.

Results

Eighteen cohort studies with 1880 patients were included in the review. The median overall

SUBMITTER: Kamarajah S 

PROVIDER: S-EPMC7061034 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature