Noninferiority and equivalence tests in sequential, multiple assignment, randomized trials (SMARTs).

ABSTRACT: Adaptive interventions (AIs) are increasingly popular in the behavioral sciences. An AI is a sequence of decision rules that specify for whom and under what conditions different intervention options should be offered, in order to address the changing needs of individuals as they progress over time. The sequential, multiple assignment, randomized trial (SMART) is a novel trial design that was developed to aid in empirically constructing effective AIs. The sequential randomizations in a SMART often yield multiple AIs that are embedded in the trial by design. Many SMARTs are motivated by scientific questions pertaining to the comparison of such embedded AIs. Existing data analytic methods and sample size planning resources for SMARTs are suitable only for superiority testing, namely for testi

SUBMITTER: Ghosh P 

PROVIDER: S-EPMC7061067 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature