Outcome After Decompressive Craniectomy for Middle Cerebral Artery Infarction: Timing of the Intervention.

ABSTRACT: BACKGROUND:Based on randomized controlled trials (RCTs), clinical guidelines for the treatment of space-occupying hemispheric infarct employ age (≤60 yr) and time elapsed since stroke onset (≤48 h) as decisive criteria whether to perform decompressive craniectomy (DC). However, only few patients in these RCTs underwent DC after 48 h. OBJECTIVE:To study the association between the timing of DC and (un)favorable outcome in patients with space-occupying middle cerebral artery (MCA) infarct undergoing DC. METHODS:We performed a single-center cohort study from 2007 to 2017. Unfavorable outcome at 1 yr was defined as a Glasgow outcome scale 1 to 3. Additionally, we systematically reviewed the literature up to November 2018, including studies reporting on the timing of DC and other predictors of

SUBMITTER: Goedemans T 

PROVIDER: S-EPMC7061200 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature