Pathophysiology and diagnosis of coronary microvascular dysfunction in ST-elevation myocardial infarction.

ABSTRACT: Early mechanical reperfusion of the epicardial coronary artery by primary percutaneous coronary intervention (PCI) is the guideline-recommended treatment for ST-elevation myocardial infarction (STEMI). Successful restoration of epicardial coronary blood flow can be achieved in over 95% of PCI procedures. However, despite angiographically complete epicardial coronary artery patency, in about half of the patients perfusion to the distal coronary microvasculature is not fully restored, which is associated with increased morbidity and mortality. The exact pathophysiological mechanism of post-ischaemic coronary microvascular dysfunction (CMD) is still debated. Therefore, the current review discusses invasive and non-invasive techniques for the diagnosis and quantification of CMD in STEMI in the

SUBMITTER: Konijnenberg LSF 

PROVIDER: S-EPMC7061278 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature