Ontology highlight
ABSTRACT:
SUBMITTER: Ma X
PROVIDER: S-EPMC7061417 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Cell metabolism 20190425 1
Tumor-infiltrating T cells often lose their effector function; however, the mechanisms are incompletely understood. We report that cholesterol in the tumor microenvironment induces CD8<sup>+</sup> T cell expression of immune checkpoints and exhaustion. Tumor tissues enriched with cholesterol and cholesterol content in tumor-infiltrating CD8<sup>+</sup> T cells were positively and progressively associated with upregulated T cell expression of PD-1, 2B4, TIM-3, and LAG-3. Adoptively transferred CD ...[more]