Damage to the shortest structural paths between brain regions is associated with disruptions of resting-state functional connectivity after stroke.

ABSTRACT: Focal brain lesions disrupt resting-state functional connectivity, but the underlying structural mechanisms are unclear. Here, we examined the direct and indirect effects of structural disconnections on resting-state functional connectivity in a large sample of sub-acute stroke patients with heterogeneous brain lesions. We estimated the impact of each patient's lesion on the structural connectome by embedding the lesion in a diffusion MRI streamline tractography atlas constructed using data from healthy individuals. We defined direct disconnections as the loss of direct structural connections between two regions, and indirect disconnections as increases in the shortest structural path length between two regions that lack direct structural connections. We then tested the hypothesis that fun

SUBMITTER: Griffis JC 

PROVIDER: S-EPMC7061444 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature