Exploring the cell-protein-mineral interfaces: Interplay of silica (nano)rods@collagen biocomposites with human dermal fibroblasts.

ABSTRACT: The benefits of associating biological polymers with nanomaterials within functional bionanocomposite hydrogels have already been evidenced both in vitro and in vivo. However their development as effective biomaterials requires to understand and tune the interactions at the cell-protein-mineral ternary interface. With this purpose, we have studied here the impact of silica (nano)rods on the structural and rheological properties of type I collagen hydrogels ​and on the behavior of human dermal fibroblasts. High collagen concentrations were beneficial to the material mechanical properties, whereas silica rods could exert a positive effect on these at both low and high content. Electron microscopy evidenced strong bio-mineral interactions, emphasizing the true composite nature of these materi

SUBMITTER: Shi Y 

PROVIDER: S-EPMC7061546 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature