Fluid and solute transport across the retinal pigment epithelium: a theoretical model.

ABSTRACT: The retina is composed of two main layers-the neuroretina and the retinal pigment epithelium (RPE)-that are separated by a potential gap termed the sub-retinal space (SRS). Accumulation of fluid in the SRS may result in a retinal detachment. A key function of the RPE is to prevent fluid accumulation in the SRS by actively pumping fluid from this space to the choroid. We have developed a mathematical model of this process that incorporates the transport of seven chemical species: Na⁺, K⁺, Cl^-, HCO3-, H⁺, CO₂ and H₂CO₃. This allows us to estimate solute and water fluxes and to understand the role of the different membrane ion channels. We have performed a global sensitivity analysis using the extended Fourier amplit

SUBMITTER: Dvoriashyna M 

PROVIDER: S-EPMC7061709 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature